ALDH2 Glu504Lys Polymorphism Contributes to CAD
نویسندگان
چکیده
143 Received March 26, 2014; revised and accepted September 5, 2014. Published online September 27, 2014; doi: 10.1620/tjem.234.143. *These authors have contributed equally to this work. Correspondence: Yuguo Chen, M.D., Ph.D., Department of Emergency and Chest Pain Center, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Ji’nan, Shandong 250012, P.R. China. e-mail: [email protected] Review
منابع مشابه
ALDH2 Glu504Lys polymorphism and susceptibility to coronary artery disease and myocardial infarction in East Asians: a meta-analysis.
BACKGROUND AND AIMS Emerging evidences have shown that the Glu504Lys variant in ALDH2 gene may greatly reduce the ability of ALDH2 to metabolize acetaldehyde, which could increase the risk of coronary artery disease (CAD) and myocardial infarction (MI). However, the reported results are still conflicting. To investigate the association between ALDH2 Glu504Lys polymorphism and the risk of CAD an...
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BACKGROUND The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism and hypertension in Asians has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the hypertension risk. METHOD An electronic literature search was conducted using the following database: PubMed, Embase and China National Knowledge Infrastructure (...
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Numerous studies have evaluated the association between Glu504Lys polymorphism in the aldehyde dehydrogenase 2 (ALDH2) gene and colorectal cancer (CRC) risk. However, the specific association remains controversial. To assess the relationship between the ALDH2 Glu504Lys polymorphism and CRC, we conducted a comprehensive meta-analysis of five case-control studies comprising 1664 patients with CRC...
متن کاملMitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.
Glyceryl trinitrate (GTN), also known as nitroglycerin, has been used to treat angina and heart failure for more than 130 years. Recently, it was shown that mitochondrial aldehyde dehydrogenase-2 (ALDH2) is responsible for formation of NO, the metabolite needed for GTN efficacy. In the present study, we show that the common G-to-A polymorphism in exon 12 of ALDH2--resulting in a Glu504Lys repla...
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تاریخ انتشار 2014